1 *Ravi Prakash, 2Manoj Bhardwaj, 2Dr Dheeraj Bisht, 1Arpit Singh, 1Vishal Verma
A B S T R A C T
Citrus flavonoids are flavonoids found in citrus fruits, such as oranges, grapefruits, limes, mandarins, pomelos, and bergamots. The review was based on the physicochemical and diverse biological properties of Hesperetin. It is a trihydroxyflavanone with a methoxy substituent at the 4′ position and three hydroxy groups at the 3′, 5′, and 7′ locations. It functions as a plant metabolite, an antioxidant, and an anti-tumor agent. It has effective role in the management of various neurological disorders i.e., AD, PD etc. In conclusion. Hesperetin is a naturally occurring substance with low toxicity, ease of access, and promising future development and use. It is a major focus to perform some chemical modification of Hesperetin in order to find a synthetic product with a high degree of bioavailability and good pharmacological efficacy. We may observe from earlier research that there is insufficient clinical data regarding Hesperetin’s therapeutic effects. Thus, further clinical research is still required to determine the proper dosage, bioavailability, effectiveness, and safety of hesperetin and its metabolites.
Keywords: Hesperetin, physicochemical, biological activities, flavonoids, toxicity.