1 *Vishal Verma, 2Dr. Manoj Bisht, 2Dr. Manoj Bhardwaj, 1Ravi Prakash, 1Arpit Singh
A B S T R A C T
The review was based on the Transungual Drug Delivery System: Nails, factors effecting drug diffusion in to nail. Antifungal nail lacquers are the result of recent developments in topical transungual administration. The goal of current nail permeation research is to modify the nail plate barrier using penetration enhancers and chemical treatments. The ungual system, or human nail, has a very different chemical makeup than other bodily membranes. The barrier properties of the plate, which is made up of keratin molecules with numerous disulphide bonds and low quantities of related lipids, are different from those of any other bodily membrane; rather, they are more akin to or specific for a hydrogel than a lipophilic membrane. The nail’s surface or plates are thicker and tougher due to the strong disulphide bonds that stop medications from entering the nail. Potential penetration of nail enhancers should permeate formulations inside the nail barrier. In conclusion, molecular size, the HLB of the diffusing molecule, the type of vehicle, the pH of the vehicle, the drug’s binding to keratin and excipients, formulation effects, nail thickness, and the existence of illness are all factors that impact drug diffusion into the nail. Surgical, systemic, and topical medication administration to the nails are examples of transungual drug delivery techniques.
Keywords: Transungual Drug Delivery System, nail, nail diseases, Factors affecting drug diffusion in to nail, topical drug delivery system.