1 *Aman Kumar, 2 Shalini Singh
A B S T R A C T
The study was based on the Phytochemical Screening and Evaluation of Anti-Ulcer Activity of Crassula ovata. The leaves of Crassula ovata were obtained from the Unnao reason. These were identified and authenticated by a botanist at BSI, Prayagraj (Ref. no.2024-25/536. The leaves were washed making dust-free and dried at room temperature or shade. The leaves were weighed and soaked into hydroalcoholic solution: Ethanol + distilled water (1:1) for fifteen days with gradual stirrings. The obtained slurry of mixture was dried under partial vacuum using a rotary evaporator. Preliminary phytochemical screening of the herbal extract was done. It was evaluated the anti-ulcer (in-vitro) effect of the Crassula ovata extract i.e., Acid Neutralizing activity and H+/K+ – ATPase Inhibition Activity. The percentage yield of the hydroalcoholic leaves extract of Crassula ovata was calculated which found to be 58.24 %. When compared to the control group hydroalcoholic leaves extract of Crassula ovata considerably modulated the H+/K+ – ATPase Inhibition Activity. It also showed an excellent acid neutralizing activity when compared with the Al(OH)3+Mg(OH)2 (as standard antacid). In conclusion, Crassula ovata might be given in the management of gastric ulcer and other gastric related problems that was effective when compared with aluminum hydroxide and magnesium hydroxide (standard antacids). It demonstrated a significant inhibition in the H+/K+ – ATPase Inhibition Activity and neutralized the gastric acid volume effectively.
Keywords: Crassula ovata, Acid Neutralizing activity, ATPase Inhibition Activity, Maceration.