1 *N S Ganesh, 1 J Adlin Jino Nesalin, 1 Sameena Afreen, 1D M Rakshitha, 1V Chandy
ABSTRACT
The study’s primary goal was to create and assess a liposomal gel that would increase
Bifonazole’s permeability, decrease its adverse effects, and improve patient compliance. Using
ethanol injection, liposomes were made with varying amounts of soy lecithin and cholesterol.
Different batches of Bifonazole-loaded liposomes were made, and their % yield, drug content,
entrapment efficiency, and in-vitro release were assessed. The drug content & entrapment
efficiency were determined to be between 47.7±0.94 and 84±0.66 and 46.2±0.33 and 82.2±0.4,
respectively. Formulation F4, which demonstrated improved drug entrapment efficiency, drug
content, and in-vitro release of Bifonazole, was determined to be the best formulation. After
employing Carbopol-940 to insert the optimized Bifonazole-loaded Liposomes into the gel, the
resulting Liposomal gel was assessed for viscosity, pH, spreadability, zeta potential, and in-vitro
diffusion. The formulated liposomal gel of Bifonazole was homogenous and clear and showed Invitro diffusion of 90.01% at the end of 6th hour.
Keywords: Liposome(s), Bifonazole, liposomal gel, Permeability.