1*Srishti Yadav, 2Dr. Prashant Kumar Singh, 3Aadhya Dubey, 4Risabh Kumar Pandey
A B S T R A C T
A method that delivers medications in the systemic circulation and avoids the pre-systemic
metabolism, such as intranasal, buccal, transdermal, and pulmonary routes, came into
awareness to address these issues. This review deals with literature inclusion from the PubMed,
Scopus, Web of Science and other reputed platforms. This article focuses on the merits,
demerits, muco-cohesion mechanisms of buccal delivery system. A muco-adhesion is described
as an interfacial adhesion in which a force of attraction holds one artificial mucoadhesive
polymer and the opposing mucin layer (mucosal tissue) together. It has numerous advantages
over other routes of administration with few drawbacks. In novel drug delivery system,
mucoadhesive films/patches were developed to boost bioavailability and lower systemic
toxicity. In conclusion, by increasing intrinsic or efficacy activity, it helps the target therapy. It
has shown how mucoadhesive substances with quick and systemic potential work. Therefore,
this strategy has become essential in the case of emergency treatment.
Keywords: Buccal drug delivery system, NDDS, merits, limitations.