1*Vanshika Dixit, 2Shalini Singh
A B S T R A C T
The study was based on the Synthesis, Characterization and Antimicrobial Screening of
Azetidinone Derivatives. After synthesis, the novel Azetidinones derivatives were characterized
for following parameters i.e., physical appearance, melting point, TLC (Rf values), FTIR
analysis, NMR analysis and Mass spectroscopy. To evaluate the anti-fungal potential of novel
Azole (1,3,4-Oxadiazole) derivatives activity through well diffusion method against fungal
strains i.e., S. aureus, Aspergillus niger, E. coli and Candida albicans. The physical
characteristics of every Azetidinones derivative that was synthesized were examined. A2
showed a yield of 0.78 %, which was its highest percentage. A4 had the lowest yield percentage,
at 0.65 %. Zone inhibition (anti-microbial activity) was recorded as 4.86 mm, 5.27 mm, 5.49
mm, and 6.34 mm in S. aureus, A. niger, E. coli and C. albicans, respectively. It can be
concluded that the anti-microbial potential was much significant against C. albicans. Its anti
microbial potential might be due to the destruction of cell wall and/ nucleic acid of diverse
microbial strains. Gentamycin as std. anti-microbial agent exhibited highest inhibition zone
ranging from 13.0 to 26.0 mm. It also showed highest zone inhibition against C. albicans as 26.0
mm.
Keywords: Azetidinones derivatives, anti-microbial, Zone inhibition NMR, FTIR.