1 *Dhirendra Kumar, 2 Smriti Gohri, 3Divya Pathak
A B S T R A C T
The synthesis and assessment of new benzothiazole compounds for anti-rheumatic activity served as the foundation for the investigation. An inflammatory kind of arthritis that can impact regions outside of the joints is rheumatoid arthritis. A ring containing nitrogen and sulfur atoms is joined to a benzene atom to form heterocyclic dicyclic compounds known as benzothiazoles. As an analgesic, anti-inflammatory, anti-diabetic, and cancer preventive, it has a number of medical applications. Using TLC, FTIR, NMR, and mass spectroscopy, new benzothiazole derivatives were created and evaluated for % yield, physical characteristics, melting point, and Rf value. The melting points of the benzothiazole derivatives C1, C2, C3, C4, C5, and C6 were found to be 8ºC, 9ºC, 12ºC, 13ºC, 11ºC, and 14ºC, respectively. The corresponding Rf values for C1, C2, C3, C4, C5, and C6 were 0.76, 0.68, 0.73, 0.65, 0.71, and 0.64. It was determined that physicochemical characteristics and spectrum analysis were used to produce and identify benzothiazole derivatives (C1–C6). Using the COX activity test and the Inhibition (%) of protein denaturation test using egg albumin, C1 was determined to be the most significant of all the derivatives when examined pharmacologically for anti-arthritic potential. Rheumatoid arthritis (RA), an auto-immune disease that severely affects a vast population globally, may benefit from its use. It will be affordable and easily accessible to humanity. The way that synthetic benzothiazole derivatives treat and stop the development of rheumatoid arthritis will be assessed by other researchers. In order to treat and stop the progression of rheumatoid arthritis, it advises other researchers to assess the mechanism of action of benzothiazole derivatives.
Keywords: Benzothiazole derivatives, rheumatoid arthritis, synthesis, characterization, spectral analysis.