1*Rishabh Singh, 2Shalini Singh
A B S T R A C T
The study was based on the design, synthesis and evaluation of new azole as antifungal agents.
After design and synthesis, the novel Azole derivatives, these were characterized the
synthesized novel Azole derivatives using following parameters i.e., physical appearance,
melting point, TLC (Rf values), FTIR analysis, NMR analysis and Mass spectroscopy. To evaluate
the anti-fungal potential of novel Azole (1,3,4-Oxadiazole) derivatives activity through well
diffusion method against fungal strains i.e., Aspergillus niger, Penicillium notatum, Candida
albicans and Rhizopus species. Zone inhibition (anti-fungal activity) of Oxadiazole (C4) was
recorded as 4.86 mm, 5.27 mm, 5.49 mm, and 6.34 mm in S. aureus, A. niger, E. coli and C.
albicans, respectively. It can be concluded that the anti-fungal potential was much significant
against Rhizopus species which proves its anti-fungal action. Its anti-fungal potential might be
due to the destruction of cell wall and/ nucleic acid of diverse fungal species. Ketoconazole as
std. anti-fungal agent exhibited highest inhibition zone ranging from 12.0 to 24.0 mm. It also
showed highest zone inhibition against Rhizopus species as 24.0 mm.
Keywords: 1,3,4-Oxadiazole derivatives, anti-fungal, NMR, FTIR.